V2EX n-cadherin

N-Cadherin

定义 Definition

N-钙黏蛋白(N-cadherin)是一种位于细胞膜上的细胞黏附分子(钙依赖性黏附蛋白家族成员),主要介导细胞与细胞之间的连接,在神经组织发育、细胞迁移、组织形态形成等过程中很重要;在肿瘤生物学中也常与上皮-间质转化(EMT)和侵袭性增强相关。(该词在不同语境下还可引申讨论“cadherin switch”等现象。)

发音 Pronunciation

/n kdhrn/

例句 Examples

N-cadherin helps cells stick together.
N-钙黏蛋白帮助细胞彼此黏附在一起。

During EMT, some tumors increase N-cadherin expression, which can promote migration and metastasis.
在上皮-间质转化过程中,一些肿瘤会提高N-钙黏蛋白的表达,从而可能促进迁移与转移。

词源 Etymology

N-通常指 neural(神经的),因为它最早与神经组织中的表达与功能密切相关;cadherin来自“calcium-dependent adhesion(钙依赖性黏附)”这一特征的命名传统,强调这类蛋白介导的细胞黏附需要钙离子参与。

相关词 Related Words

文学与著作 Literary Works

  • Molecular Biology of the Cell(Alberts 等)在细胞连接与黏附分子章节中讨论cadherins(包括N-cadherin)。
  • The Biology of Cancer(Robert A. Weinberg)在肿瘤进展、EMT与转移相关内容中常提及N-cadherin与“cadherin switch”。
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