V2EX e-cadherin

E-cadherin

定义 Definition

E-cadherin(E-钙黏蛋白)是一种主要存在于上皮细胞表面的细胞黏附蛋白,帮助细胞彼此紧密连接、维持组织结构与屏障功能;在癌症研究中常作为“上皮特征”标志物,其表达降低常与上皮-间质转化(EMT)和肿瘤侵袭/转移相关。(该词也可泛指相关通路或检测指标。)

发音 Pronunciation (IPA)

/i kdhrn/

例句 Examples

E-cadherin helps epithelial cells stick together.
E-cadherin 帮助上皮细胞彼此黏附在一起。

Loss of E-cadherin expression is often associated with increased cell migration and tumor invasiveness.
E-cadherin 表达的降低常与细胞迁移增强和肿瘤侵袭性增加相关。

词源 Etymology

“Cadherin”来自“calcium-dependent adhesion”(钙依赖性的黏附)这一概念的缩合与构词:cad- 指与“calcium(钙)”相关,-herin 与“adhere(黏附)”相关;“E-”表示“epithelial(上皮)”,说明这种钙黏蛋白最典型地与上皮细胞黏附有关。

相关词 Related Words

文学与著作中的用例 Literary & Notable Works

  • 《Molecular Biology of the Cell》(Alberts 等):在细胞连接与细胞黏附章节中讨论 E-cadherin 与黏着连接(adherens junction)。
  • 《The Biology of Cancer》(Robert A. Weinberg):在肿瘤侵袭、转移与 EMT 的语境中提到 E-cadherin 的变化。
  • 经典综述/研究论文中高频出现:如围绕 EMT 与转移机制的论文常以 E-cadherin 作为关键标志物与机制节点讨论。
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