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惠郎教授

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惠郎 教授

教授

+886-6-275-7575 ext. 65601

+886-6-2766505

子信箱

hlyang@mail.ncku.edu.tw

水物疾病室(台南市大路一成功校大六)

授程

97年度第一期

乙 (一)

利特

96年度第二期

乙 (二)

研究特 (二

生物技利特

  1. 加州大(Davis) Bacteriology Ph.D(1972)
  2. 立台大化系士(1966)

  1. 立成功大特聘教授(2002- )
  2. 立成功大生物科技研究所所(2000- )
  3. 立成功大生物科技研究所教授(2000- )
  4. 立成功大生物科技中心副主任(2000- )
  5. 立成功大生物技研究中心主任(2000- )
  6. 中央研究院生物科研究所研究(1998- )
  7. 立台大系兼任教授(1994- )
  8. 法人生物技中心分子生物主任)(1991-1997)
  9. 立明院客座教授(1990-1991)
  10. Managing Director of Research and Development, ENZO Diagnostics Inc.(1988-1990)
  11. Director, Recombinant DNA / Microbiology, ENZO Biochem, Inc.(1984-1988)
  12. Associate Director, Recombinant DNA, ENZO Biochem, Inc.(1982-1984)
  13. Associate, Department of Genetics, The Public Health Research Institute in the City of New York (1980-1982)
  14. Adjunct Assistant professor, New York University, School of Medicine (1980-1982)
  15. Senior Research Associate, Department of Biological Sciences, Columbia University (1977-1980)

及研究域

  1. 生物技
  2. 疫苗技
  3. 科技管理

及 (至少五年)

  1. l986  NIH  Technique Ad Hoc committee for SBIR grant
  2. l987  NIH  Technique Ad Hoc Committee for SBIR grant
  3. Invited lecture speaker in the l987 DNA Probe Conference held in San Diego,  CA.. sponsored by AACC
  4. Invited lecture speaker in the l987 "Immunological Conference" held in Sarasota Fl. sponsored by Engineer Foundation
  5. 行政院81年度出科技人才--生物技
  6. Member of editorial board of  Asia-Pacific Journal of Molecular Biology and Biotechnology
  7. Food Science and Agricultural Chemistry Journal: Editorial board 1999
  8. 科生物87年度甲 研究 

利 (至少五年)

  1. 中民利: 明第227114:水生物用口服疫苗 2005年2月1日至2022年9月4日
  2. US 6,777,247, Nervous necrosis virus protein (Aug.17, 2004)
  3. US Application No.: 09/946,273 , ORAL VACCINES Filing Date: September 5, 2001 , Approved date. Nov. 2004.
  4. 0124124: Methods and materials useful for the analysis and detection of genetic material ( Inventor : Yang, Kirtikar and Pergolizzi ).Publication date: 1984. 07.11 Country designated:11: AT, BE, CH, DE, Fr, GB, IT, LI, LU, NL, SE
  5. 0133473: In Vivo labeling of polynucleotide sequuences ( Inventor: Stra-        vrianopoulus, Yang and Kelker ). Publication date: 1985. 02.27 Country designated: 11: AT, BE, CH, DE, FR, GB, IT, LU, LI, NL, SE
  6. 0294595: Polynucleotide composition and method for its production ( Inventor : Yang and Donegan ). Publication date: 1988. 12.14 Country designated: 13: AT, BE, CH, DE, ES, FR, GB, IT, LI, LU, NL, SE
  7. 0237737: Nucleic acid probes specific for Neisseria gonorrhea and method for screening for a nucleic acid sequence specific for a genetically distinct group (Inventor: Lo and Yang ). 1987. 09. 23 Country designated: 9: BE, CH, DE, FR, GB, IT. LI, NL, SE
  8. 0343424: Method for sample adherence to test substrate (Inventor: Yang, Todd and Jou ) . Publication date: 1989.11.29 Country designated: 4: DE, FR, GB, IT
  9. 4900659: Nucleotide sequence composition and detection of Neisseria  gonorrheae and method for screening for a nucleotide sequene that is specific for a genetically distinct group (Inventor : Lo and Yang ) . 1990. 2. 13
  10. 4987065: In vivo labeling of polynucleotide sequences (Inventor : Stravrianopoulus, Yang and Kelker ). 1991. 6. 22
  11. 5024933: Method and kit for sample adherence to test substrate ( Inventor :     Yang, Todd nd Jou ). 1991. 6. 18
  12. 1299073 : April 21, 1992 Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for genetically distinct group Inventor: Andrew Lo and Huey-Lang Yang
  13. 1338856: Jan 21, 1997 In vivo labeling of polynucleotide seqeunce Inventor: N. Kelker, J. Stavrianopoulos, Huey-Lang Yang
  14. 1,339,249: Aug. 12,1997 Method for sample adherence to test substrate Inventor : H-L. Jou, J. Todd and Huey-Lang Yang Yang
  15. 1,340,100:Oct 27, 1998 Polynucleotide composition and method Inventor : J. Donegan and Huey-Lang Yang
  16. 2607058   Feb 13, 1997 A method for in vitro labeling polynucleotide Stravrianopoulus, Yang and Kelker
  17. 2540482  July 8, 1996 In vitro labeling of polynucleotide sequence Stravrianopoulus, Yang and Kelker
  18. 081902 1996.10.17台型EB病毒的促因子(ZEBRA)抗原蛋白之方法
  19. 080691 1996.10.01利用基因工程技具有EB病毒DNA polymerase 抗原蛋白之方法
  20. 83108294,371671本土性假性狂犬病毒gE之基因及其醣蛋白,其方法及用途 (1999年)
  21. 本土性假性狂犬病gX-gP63-gp50-gI基因及TK基因之核酸序列gI基因及TK基缺病毒之法及用途 (1995年申,核中)
  22. 本土性假性狂犬病毒之二或多株,及其法用途(1996年申,核中)
  23. 使用去毒性蛋白研免疫生育控(1996年申中)
  24. Nucleotide sequences of Nervous Necrosis Virus and its application(申美及盟美利中)
  25. A fish oral vaccine method with bioencapsulation of recombinant bacterium(申美及名利中)

著作 (至少五年)

A. Refereed Papers
  1. Review: 振文,戴,惠郎。1997。以免疫去控物之生殖。科。 45(5,6):176-185 .
  2. Review: 振文,瑞珍,戴,惠郎,宋永。1997。逢多性核甘酸在畜之用。科45(9,10):275-283.
  3. 振文,戴,宋永,惠郎1998。核酸疫苗研之物模式 46:(5, 6): 209-216
  4. 振文,施勇,惠郎,戴,宋永。1998。生分化因子之生物功能。46(11,12):366-375。
  5. 惠郎,振文,戴,宋永。1998生物技在畜上之用畜研究 31: (2) 197-210
  6. M.Y.Liu, Y.L.Chang, J.Ma, H.L.Yang, M.W.Hsu, C.J.Chen, J.Y.Chen, C.S.Yang。1997。 Evaluation of multiple antibodies to EB us as markers for detecting patients with nasopharyngeal carcinoma J. of Medical Virology 52:262-269 .
  7. ReviewHuey-Lang Yang1999。The application of new biotechnology for disease prevention in animal pp. 73-82 in “ Biotechnology in agriculture in Asia, Asian productivity Organization.
  8. J.W.Shiau, T.K. Tang, Y.L. Shih, C.Tai, Y.Y.Sung, J.L.Huang, H.L.Yang.。2000。 Mice immunized with DNA encodes a modified Pseudomonas aeruginosa exotoxin A develops protective immunity against exotoxin intoxication . Vaccine Vol. 19, issue 9-10, 1106-1112(SCI) .
  9. J.P.R. Rajan, Carmen Lopez, John Han-You Lin, Huey-Lang Yang. 2001。Infection of Vibrio alginolyticus on cultured cobia, Rachycentron canadum in Taiwan. Bulletin of the European Association of Fish pathologist 21(6), 228-235(SCI)
  10. Carmen Lopez, J.P.R. Rajan, John Han-You Lin, Tsun-Yung Kuo & Huey-Lang Yang. 2002 Disease outbreak in seafarmed Cobia (Rachycentron canadum) associate with Vibrio spp., Photbacterium damselae ssp piscida, monogenean and mycosporean parasites Bulletin of the European Association of Fish pathologist 22(3), 206-211.
  11. Lopez C, J.P.R. Rajan, John Han-You Lin, Tsun-Yung Kuo & Huey-Lang Yang. (2002)Disease outbreak in seafarmed Cobia (Rachycentron canadum) associate with Vibrio spp., Photbacterium damselae ssp piscida, monogenean and mycosporean parasites Bulletin of the European Association of Fish pathologist 22 (3), 206-211.
  12. P.R. Rajan, John H-Y Lin, M-S. Ho and H-L. Yang, (2003) Simple and rapid detection of Photobacterium damselae subsp. piscida by a PCR technique and plating method Jour of Applied Microbiology ,(J. of Applied Microbiology 2003, 95, 1375-1380. (PDF download)
  13. H.S. Kuo, Y-L Su, H-L. Yang, and T.Y. Chen, (2005) Identification of Chinese medicinal fungus Cordyceps sinensis by PCR-single stranded conformation polymorphism and phylogenetic relationshipJ. Agri. Food Chem. (PDF download)
  14. Yang, H.-L., Chien-Chih Yu, and John Han-You Lin, ?Fish oral delivery system using Artemia encapsulated with recombinant E. coli. International Association for Biologicals.: Progress in fish vaccinology. (ed) Midlyng PJ, Dev. Biol. Basel, Kreger, 2005, Vol. 121, pp 175-180, 2005
  15. Han-Tso Lin, Han-You Lin, Huey-Lang Yang,( 2005) Studies of the Histology and Histochemical Enzyme-Staining Patterns of Major Immune Organs in Malabar Grouper (Epinephelus malabaricus, Bloch et Schneider), Journal of Fish Biology 66, 729-740. (PDF download)
  16. Chen SP, Yang HL, Her GM, Lin HY, Jeng MF, Wu JL, Hong JR. (2006) Betanodavirus induces phosphatidylserine exposure and loss of mitochondrial membrane potential in secondary necrotic cells, both of which are blocked by bongkrekic acid. Virology 347(2):379-91. (PDF download)
  17. Chen YM, Su YL, Lin JH, Yang HL,Chen TY. (2006)Cloning of an orange-spotted grouper (Epinephelus coioides) Mx cDNA and characterisation of its expression in response to nodavirus. Fish Shellfish Immunol 20(1):58-71. (PDF download)
  18. Chen SP, Yang HL, Lin HY, Chen MC, Wu JL, Hong JR. (2006)Enhanced viability of a nervous necrosis virus-infected stable cell line over-expressing a fusion product of the zfBcl-xL and green fluorescent protein genes. J Fish Dis 29(6):347-54. (PDF download)
  19. Kuo H-C, Su Y-L, Yang H-L., Huang I-C, and Chen T-Y*. Differentiation of Cordyceps sinensis by A PCR-Single-Stranded Conformation Polymorphism Based Method and Characterization of the Fermented Products in Taiwan. FOOD BIOTECHNOLOGY 2006;20:161-170.
  20. John Han-You Lin, Tzong-Yueh Chen, Ming-Shyan Chen, Huey-En Chen, Ray-Liang, Chou, Z. Y. Cheng, M. S. Su, and Yang, H.-L.* Vaccination with three inactivated pathogens of cobia (Rachycentron canadum) stimulates protective immunity AQUACULTURE 255, 2006:125-132
  21. Lin C.-C *, Lin J H-Y *, Chen M.-S and Yang, H.-L.*. An oral Nervous Necrosis Virus vaccine that induces protective immunity in larvae of grouper (Epinephelus coioides). AQUACULTURE 2007;268:265-273
  22. Ou M-C, Chen Y-M, Jeng M-F, Chu C-J, Yang, H.-L., and Chen T-Y*. Identification of Critical Residues in Nervous Necrosis Virus B2 for dsRNA-binding and RNAi-inhibiting Activity through by Bioinformatic Analysis and Mutagenesis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;361:634-640
  23. Chen Y-M, Wei C-Y, Chien C-H, Chang H-W, Huang S-I, Yang, H.-L., and Chen T-Y*. 2007. Myostatin Gene Organization and Nodavirus-influenced Expression in Orange-spotted Grouper (Epinephelus coioides). Comp. Biochem. Physiol. D, Genomics Proteomics 2:215-227
  24. Lin H-T, Lin J H-Y, Lopez C, Chen Tzong-Yueh, Chen M-S, and Yang H-L. 2008. A Comparison of the Expression of immunity-related rag-1 and ikaros Genes with Histogenesis of the Thymus in Epinephelus malabaricus (Bloch & Schneider). Aquac. Res. 39:252-262. (PDF download)
  25. Chen Y-M, Su Y-L, Shie P-S, Lin J H-Y, Yang H-L, and Chen Tzong-Yueh. 2008. Grouper Mx Confers Resistance to Nodavirus and Interacts with Coat Protein. Dev. Comp. Immunol. 32:825-836. (PDF download)
  26. Kuo H-C, Su Y-L, Yang, H.-L., and Chen T-Y*. 2008. Establishment and Application of PCR-SSCP Profile for Molecular Typing of Cordyceps Fungi. Revised to Food Biotechnol. In press(SCI)

 

B. Conference papers

a.

 

1. Keynote speaker: Development of disease prevention system for warm water fish aquaculture, 2004
International Conference of Marine science and technology, 13-14, 2004, Kao-Hsiung, Taiwan

2. Invited speaker. The development of an oral Nervous Necrosis virus vaccine and its efficacy test in grouper, International Biotech Conference & Exhibition (IBC&E) Nov. 25-27, 2004, Ka0-Hsing, Taiwan

3. Invited oral presentation: Fish oral vaccine with recombinant E. coli. encapsulated in brine shrimp induces protective immunity 2003, 3rd International Symposium of fish vaccinology. Bergen, Norway.

4. Invited oral presentation: The development of fish disease system December 1-4, 2003
International marine biotechnological science & industry conference at National Museum of Marine Biology and Aquarium, Taiwan

5. Invited speaker: The development of vaccination program for NNV infection in grouper, 2002
International symposium on agricultural biotechnology.

6. Han-Tso Lin, C. Lopez, H. Y. Lin and H-L. Yang. How soon the grouper can arm itself?  International symposium on agricultural biotechnology, Dec. 13-14, 2002 Poster award

7. H.C. Kuo, H.L. Yang and T. Y. Chen, Phylogenetic analysis of the Chinese herb medicine Cordycepes sinensis based on 18 S rRNA gene.  International symposium on agricultural biotechnology, Dec. 13-14, 2002

6. Invited speaker: Immuno-response to killed and recombinant subunit vaccines of Nervous necrosis Virus in groper. 2001
Taiwan-Norway-USA International Symposium on fish virus pathogenesis and disease control, 2001. Sept. 27-31

7.Invited speaker: Fish oral vaccine method combining bio-encapsulation and recombinant DNA technology,2001
Asian aquaculture forum Nov. 25-29, 2001

8. Invited speaker: The application of biotechnology for the development of fish viral vaccine, Taiwan-Japan conference in Biotechnology for Aquatic animals, April 2001, Tokyo Japan

9.  Invited speaker: Fish oral vaccine method combining Bio-encapsulation and recombinant DNA technology. Taiwan-Norway-USA International Symposium on fish virus pathogenesis and disease control 2001. Sept. 27-31.

10 Invited speaker: Immuno-response to killed and recombinant subunit vaccines of Nervous necrosis Virus in groper. Taiwan-Norway-USA International Symposium on fish virus pathogenesis and disease control   2001. Sept. 27-31

11.H.L.Yang. (2001) The development of recombinant subunit vaccine for Nervous Necrosis Virus  International Conference on fish disease: European Fish Pathologist Dublin, Sept. 7-12, 2001.

12.Vibrosis in cultured cobia, Rachycentron canadum, L in Taiwan, Asian aquaculture forum  Nov. 25-29, 2001.

13.Invited speaker: Fish oral vaccine method combining bio-encapsulation and recombinant DNA technology, Asian aquaculture forum Nov. 25-29, 2001.

14.Immuo-response to killed vaccine and recombinant subunit vaccine of nervous necrosis Virus in grouper, Asian aquaculture forum Nov. 25-29, 2001.

15.Poster session: Cheng-Chieh Wang, John Han-You Lin, Chin-Chiu Lin, Tzong-Yueh Chen, and Yang H.-L. Cloning of rag-1 gene from cobia, Rachycentron canadum, and its expression during ontogenesis 2003, 3rd international Symposium of fish vaccinology

16.Poster session: John H.Y. Lin*, T. Y. Kuo+, H.C. Liang*, I.C. Huang#, and Yang H.-L.*,# The development and characterization of cell lines of grouper (Epinephelus coioides) and cobia (Rachycentron canadum) 2003, 3rd international Symposium of fish vaccinology

17.Lin S-C, Yang H.-L., and Chen Tzong-Yueh.? 2003.? Development of Nonspecific Binding Sequence and Non-cell Specificity for DNA Delivery System. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P52

18.Chen Y-M, Yang H.-L., and Chen Tzong-Yueh.? 2003.? cDNA clonging of Myxovirus Resistance (Mx) Gene, an INF-inducible Antiviral Protein from the Grouper (Epinephelus coioides). The 2003 Annual Conference of the Fisheries Society of Taiwan. Kaohsiung, Taiwan, Abs. #B-3-1

19.Huang S-I, Lin S-C, Yang H.-L., and Chen Tzong-Yueh.? 2004.? Development of a Universal DNA Delivery System. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P106

20.Chuang H-C, Chen Y-M, Yang H.-L., and Chen Tzong-Yueh.? 2004.? Study the Antimicrobial activity of Penaeidins. The 19th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Abs. #P16.

21.Chen Y-M, Mao M-H, Su Y-L, Chuang H-C, Yang H.-L., Lin H-Y, and Chen Tzong-Yueh.? 2004.? Proteomic Approach Identifies Small Heat Shock Protein as a Potentially Biomarker to Monitor Nervous Necrosis Virus Infection. 2004 International Conference of Advanced Biotechnology-Dialogue between Proteomics and Biotechnology, Tainan, Taiwan, Abs. #P2.

22.Chen Y-M, Su Y-L, Yang H.-L., and Chen Tzong-Yueh.? 2004.? The Characterization and Expression of the Mx Protein in the Grouper Cell Line. The 2004 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #A-1-2.

23.Chen Y-M, Wei C-Y, Chang H-W, Yang H.-L., and Chen Tzong-Yueh.? 2004.? Cloning, Characterization and Application of the Grouper (Epinephelus coioides) Myostatin Gene. The 2004 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #A-5-6.

24.Chen Y-M, Mao M-H, Su Y-L, Chuang H-C, Yang H.-L., Lin H-Y, and Chen Tzong-Yueh.? 2004.? Proteomic Approach Identifies Small Heat Shock Protein as a Potentially Biomarker to Monitor Nervous Necrosis Virus Infection. The 2004 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #E-C5.

25.Lin H-Y, Chen Tzong-Yueh, Chen M-S, Chen H-E, Su Y-L, ChouT-I, Su M-S, and Yang H.-L. 2004. Development of a Multivalent Bacterial Vaccine for Vibrio alginolyticus, V. parahaemolyticus and Photobacterium damselae Subspecies piscicida and Its Evaluation in Cobia (Rachycentron canadum) . The 2004 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #E-32.

26. Keynote speaker: Development of disease prevention system for warm water fish aquaculture, 2004. 2004 International Conference of Marine science and technology, 13-14, 2004, Kaohsiung, Taiwan

27. Invited speaker: The development of an oral Nervous Necrosis virus vaccine and its efficacy test in grouper, International Biotech Conference & Exhibition (IBC&E) Nov. 25-27, 2004, Kaohsiung, Taiwan

28. Huang S-I, Yang  H.-L., and Chen Tzong-Yueh.  2005. Development of a Universal Biological Materials Delivery System. The 20th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Abs. #P38

29. Su Y-L, Chen Y-M, Yang H.-L., and Chen Tzong-Yueh.  2005.  The Characterization and Expression of the Mx Protein in the Grouper Cell Line. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P111.

30. Chen Y-M, Wei C-Y, Chang H-W, Yang H.-L., and Chen Tzong-Yueh.  2005.  Cloning of the Grouper (Epinephelus coioides) Myostatin Gene. The 2005 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #BO-12.

31. Chen Y-M, Su Y-L, Shie P-S, Yang H.-L., and Chen Tzong-Yueh.  2005.  Resistance to Nodavirus Activity by Coat Protein Interaction with the Interferon-regulated GTP-binding Proteins, Grouper Mx. The 2005 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. # BO-13.

32. Ou M-C, Chuang H-C, Chen Y-M, Lee G-B, Lee S-S, Yang H.-L., and Chen Tzong-Yueh.  2005.  Development of Diagnostic methods for Nervous Necrosis Virus. The 2005 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. # AP-6.

33. Chien C-H, Chen Y-M, Wei C-Y, Yang H.-L., and Chen Tzong-Yueh.  2005.  Functional Analysis of the Grouper Myostatin Gene Promoter and the Application of Myostatin in Grouper. The 2005 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. #BP-7.

34. Shie P-S, Chen Y-M, Su Y-L, Yang H.-L., and Chen Tzong-Yueh.  2005.  The Characterization and Expression of the Mx Protein in the Grouper Cell Line. The 2005 Annual Conference of the Fisheries Society of Taiwan, Taipei, Taiwan, Abs. # BP-15.

35. Chen Y-M, Su Y-L, Shie P-S, Yang H.-L., and Chen Tzong-Yueh.  2006.  Modulation of Nodavirus Coat Protein Localization by Binding to the Interferon-regulated GTP-binding Proteins, Grouper Mx. Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P101.

36. Liu Y-R, Huang S-I, Yang H.-L., and Chen Tzong-Yueh.  2006.  Characterization and Functional Analysis of a Delivery System Mediated by Protein Transduction Domain. The 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Abs. #P649.

37. Chen Tzong-Yueh, Chen Y-M, and Yang H.-L.. 2006. Identification and Characterization of the Responsive Genes in Grouper for Nervous Necrosis Virus Infection. 2006 Symposium on Biotechnology Development in Taiwan: Biotechnology in Aquaculture, Tainan, Taiwan, Abs. #S10.

38. Chen Y-M, Su Y-L, Shie P-S, Yang H.-L., and Chen Tzong-Yueh. Inhibition of Nodavirus Activity by Binding Directly to the Mx Protein in Grouper (Epinephelus coioides) Cell. Aquaculture 2006, Florence, Italy, Abs

39.Ou M-C, Chuang H-C, Chen Y-M, Lee G-B, Lee S-S, Yang H.-L., and Chen Tzong-Yueh. 2006. Development of Fast and Sensitive Diagnostic Methods for Nneverous Necrosis Virus by Using Microfluidic Chip and Real-time PCR. Aquaculture 2006, Florence, Italy, Abs.

40. Chuang H-C, Chen Y-M, Lin H-Y, Yang, H.-L., and Chen T-Y*. 2006. Detection of Nerve Necrosis Virus by a Real-time PCR Method and Characterization of Its Tissue Distributions in Giant Grouper (Epinephelus lanceolatus). VNN 2006 First International Symposium on Viral Nervous Necrosis of Fish, Hiroshima, Japan, Abs.#PP-4.

41. Ou M-C, Chen Y-M, Jeng M-F, Yang, H.-L., and Chen T-Y*. 2006. Identification of Orange-spotted Grouper (Epinephelus coioides) Nervous Necrosis Virus (OGNNV) B2-Arg53 as a Critical Residue for dsRNA Binding Activity. VNN 2006 First International Symposium on Viral Nervous Necrosis of Fish, Hiroshima, Japan, Abs.#PP-7.

42. Chen Y-M, Su Y-L, Shie P-S, Yang, H.-L., and Chen T-Y*. 2006. Inhibition of Nodavirus Activity by Binding Directly to the Interferon-regulated GTP-binding Proteins, Grouper Mx. The 40th Annual Meeting of the Taiwan Society of Microbiology, Taipei, Taiwan, Abs. #V-4.

43. Chen Y-M, Su Y-L, Shie P-S, Yang, H.-L., and Chen T-Y*.  2006.  Resistance to Nodavirus Activity by Coat Protein Interaction with the Interferon-regulated GTP-binding Proteins, Grouper Mx. The 2006 Annual Conference of the Fisheries Society of Taiwan, Keelung, Taiwan, Abs. # BO-16.

44. Liu Y-R, Ou M-C, Chen Y-M, Yang, H.-L., and Chen T-Y*.  2006.  Relations Between Structure and RNAi Inhibition Activity of Nervous Necrosis Virus B2 Protein. The 2006 Annual Conference of the Fisheries Society of Taiwan, Keelung, Taiwan, Abs. # APN-1.

45. Chen Y-M, Su Y-L, Shie P-S, Yang, H.-L., and Chen T-Y*.  2006.  Resistance to Nodavirus Activity by Coat Protein Interaction with the Interferon-regulated GTP-binding Proteins, Grouper Mx. The 2006 Annual Conference of the Fisheries Society of Taiwan, Keelung, Taiwan, Abs. # BP-6.

46. Tasi T-J, Ou M-C, Chen Y-M, Lee G-B, Lee S-S, Yang, H.-L., and Chen T-Y*.  2006.  Fast Detection Method Using NNV RNA1 as Target by Microfluidic Chip. The 2006 Annual Conference of the Fisheries Society of Taiwan, Keelung, Taiwan, Abs. # BPN-14.

47. Yu-Chin Su, Yang, H.-L., Jiann-Ruey Hong*. 2006. RGNNV B2 as a novel death gene induces grouper liver cell death. 2006 The 21th Joint Annual Conference of Biomedical Sciences March 18-19; O058, p. 74.

48. Chien-Li Chiu, Jen-Leih Wu, Yang, H.-L. and Jiann-Ruey Hong*. 2006. IPNV VP3 as a novel viral death gene, targeting to ER and induces apoptosis through caspase activation in a zebrafish cell line. 2006 The 21th Joint Annual Conference of Biomedical Sciences, March 18-19; O063, p. 76.

49. Po-Chun Chen, Jen-Leih Wu, Yang, H.-L. and Jiann-Ruey Hong*. 2006.  Src tyrosine kinase may mediate in IPNV-induced apoptosis cell death. 2006 The 21th Joint Annual Conference of Biomedical Sciences, March 18-19; P674, p. 276.

50. Speaker:S. P. Chen, Yang, H.-L., J. L. Wu and J. R. Hong. 2006. NOV 28-DEC 1. Betanodavirus induces mitochondria-mediated cell death in grouper cells.VNN 2006-First international symposium on viral nervous of fish. PP6. Hiroshima, Japan.

51. Y. C. Su, Yang, H.-L.,  J. L. Wu and J. R. Hong. 2006.  Cloning and characterization of a non-structural protein B2 as a death inducer from betanodavirus. VNN 2006-First international symposium on viral nervous of fish. PP6. Hiroshima, Japan.

52. Yang, H.-L., H.Y. Lin and C.C. Lin. 2006. Nov 28. The development of an oral NNV vaccine and its efficacy evaluation in the larvae of Epinephelus coioides. 1st International symposium on viral nervous necrosis of fish, Hiroshima, Japan.

53. H.Y Lin, Y.M Chen, M.S. Chen, C.C. Lin and Yang, H.-L.. 2006. Nov 28. Mornitoring nervous necrosis virus infection in a commercil grouper hatchery in Taiwan. 1st International symposium on viral nervous necrosis of fish, Hiroshima, Japan.

54. C.C. Lin, M.S. Chen, H.Y. Lin and Yang, H.-L.. 2006. Nov 28. Establishment of experimental challenge model of grouper (Epinephelus coioides) for NNV. 1st International symposium on viral nervous necrosis of fish, Hiroshima, Japan.

55. Chen Y-M, Su Y-L, Shie P-S, Yang, H.-L., and Chen T-Y*.  2007.  The Role of Grouper Mx Confers Resistance to Nodavirus. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P107.

56. Yang, H.-L., Chen T-Y*, and Liu Y-R.  2007.  Production and Characterization of a Peptide-Based DNA Delivery System. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Abs. #P539.

57. Chen Y-M, Yang, H.-L., and Chen T-Y*.  2007. Identification of Responsive Proteins for Nervous Necrosis Virus Infection by Proteomic Approach. The Seventh International Symposium on Fish Immunology. Stirling, Scotland, Abs. #P38.

58. Invite speaker: The development of an oral NNV vaccine and its application in commercial hatchery, The 3rd Malaysia international Agro-Bio Business Conference, 12-13 , 2007 Kuala Lumpur, Malaysia

59. Session leader: The agriculture and aquaculture biotechnology and opportunity, The 3rd Malaysia international Agro-Bio Business Conference, 12-13 , 2007 Kuala Lumpur, Malaysia

60. Invited speaker: The control of NNV infection by an oral vaccine, Asian-Pacific Aquaculture 2007 Conference, Hanoi, Aug.6-9, 2007

61.Invite speaker: The development of an oral NNV vaccine and its application in commercial hatchery, The 3rd Malaysia international Agro-Bio Business Conference, 12-13, 2007 Kuala Lumpur, Malaysia

62. Session leader: The agriculture and aquaculture biotechnology and opportunity, The 3rd Malaysia international Agro-Bio Business Conference, 12-13 , 2007 Kuala Lumpur,   Malaysia

63. Invited speaker: The control of NNV infection by an oral vaccine, Asian-Pacific Aquaculture 2007 Conference, Hanoi, Aug.6-9, 2007

64. Chen Y-M, Yang, H.-L., and Chen T-Y*. 2007. Identification of Responsive Proteins for Nervous Necrosis Virus Infection by Proteomic Approach. The Seventh International Symposium on Fish Immunology. Stirling, Scotland, Abs. #P38.

65.Lin H.-Y., Chen Y.-M. , Wu P.-F., Chen J.-Y., and Yang H.-L. 2008. Development a gene-deleted subunit vaccine of Aeromonas hydrophila. WAS 2008, Busan, Korea.

 

b.

1.      Invited speaker 。2001。 水物疾病防治生物技,水年Nov. 24, 2001

2.      ,王俊,林翰佑,宗,惠郎,以海rag-1 Ig基因之表探其免疫制之育, 九十一年度水年

3.      ,王俊,林翰佑,宗,惠郎,海重要免疫基因rag-1 Ig部份基因之殖及序列比, 九十一年度水年

4.                       周宜黎、金洌、惠郎、洪健睿。2004 。染性胰死病毒凋亡基因VP3藉由活化caspase-8  和-3 使胞凋亡。中民微生物九十三年度文表摘要。第16。

5. 洪健睿、官柏志、惠郎、金洌。2004 。胰死病毒感染能活化因子NF-kB去促使胞凋亡和降低病毒蛋白表之双功能角色。水九十三年度文表摘要。第3。

6. 郁清、惠郎、金洌、洪健睿。2004 。神死病毒非性蛋白基因B2可石斑肝胞株凋亡及可被小片段干性RNA其功能。水九十三年度文表摘要。第10。

7. 曹儒,林翰佑,惠郎. 2006. Dec 16.  石斑丁化,功能性分析及基因殖. 台水年文表. 基隆,台。

8. 佩芬,林翰佑,惠郎. 2006. Dec 16.  Aeromonas hydrophia 的Aerolysin毒素之毒性分析. 台水年文表. 基隆,台。

9.俐伽、郁清、惠郎、金洌、洪健睿。2006. 神死病毒B1新表之基因及其胞分之研究。2006台水。BO-25; pp24。

10.Chen Y-M, Su Y-L, Shie P-S, Yang, H.-L., and Chen T-Y*.  2007.  The Role of Grouper Mx Confers Resistance to Nodavirus. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, Abs. #P107.

11. Yang, H.-L., Chen T-Y*, and Liu Y-R.  2007.  Production and Characterization of a Peptide-Based DNA Delivery System. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Abs. #P539.

12. Chen Y-M, Shie H-P, Yang H-L, and Chen T-Y*. 2007. Identification of Responsive Proteins for Nervous Necrosis Virus Infection by Proteomic Approach. Taiwan Proteomics Society International Conference 2007. Tainan, Taiwan, Abs. #P83.

13. Chen Y-M, Shie H-P, Yang H-L, and Chen T-Y*.  2007.  Proteome analysis of viral nervous necrosis grouper by two-dimensional electrophoresis. The 2007 Annual Conference of the Fisheries Society of Taiwan, Kaohsiung, Taiwan, Abs. # BO-2-2.

14. Chen Y-M, Shie P-S, Yang H-L, and Chen T-Y*.  2008. Roles of grouper Mx in regulation of cell cycle and resistance to nodavirus. The 7th Symposium on Diseases in Asian Aquaculture. Taipei, Taiwan, Abs. CP#35.

15. Chen Y-M, Shie H-P, Yang H-L, and Chen T-Y*.  2008.  Identification of small heat shock protein as stress-induced molecular chaperone-like activity in nodavirus infected grouper. The 7th Symposium on Diseases in Asian Aquaculture. Taipei, Taiwan, Abs. PB#159.

16. Tasi T-J, Lee S-S, Chen Y-M, Lee G-B, Yang H-L, and Chen T-Y*.  2008.  One step multiplex diagnosis for grouper pathogens detection. The 7th Symposium on Diseases in Asian Aquaculture. Taipei, Taiwan, Abs. PB#98.

17. Chen L-J, Su Y-C, Yang, H-L. Wu J-L and Hong J-R . 2007. RGNNV B1 protein plays an anti-apoptotic function with RGNNV infection in grouper fish cells. 2007 The 22th Joint Annual Coference of Biomedical Sciences, Taiwan. P607. [秀壁文]

18. Chen L-J, Su Y-C, Yang, H-L. Wu J-L and Hong J-R . 2007. Identification of RGNNV protein B1 as a novel anti-apoptotic death gene. Annual meeting of the fisheries society of Taiwan, AO-2-3.

19. Shih C.-H., Liu H.-C., Wu C.-L., Lin C.-C., Chen Y.-M., Lin H.-Y., and Yang H.-L. 2008. Vibrio expression system: a novel host for nervous necrosis virus subunit vaccine production. DAA VII, Taipei.

20. Chang C-W, Chen L-J, Su Y-C, Yang, H-L. Wu J-L and Hong J-R. 2008. Identification of a novel antiapoptotic protein B1 encoded by the RGNNV TN1 strain in fish cells. The 7th Symposium on Diseases in Asian Aquaculture, June 22-26, Taipei, Taiwan. PB60

21. 施宏,,政隆,林青丘,逸民,林翰佑,惠郎。2007。利用弧菌表神死病毒口服次位疫苗之有效性估。台水96年度文表,文摘要。

 

C. 及文

  1. 物疫苗:疫苗展技,教育部民九十三年
  2. 水用疫苗:疫苗展技,教育部民九十二年
  3. 我生技展策略之分析及建, (科技展政策月刊中民九十年十月SR 9010 PP. 761-765)
  4. 用疫苗, (生物技展,九州出版社)
  5.   ,惠郎。(2001)。我生技展策略之分析及建。科技展政策。SR90010,P761-765。
  6. 惠郎、林青丘、林翰佑。石斑稚NNV口服疫苗之研:生物科技2005秋季 PP.17-22。立中大生物科技展中心。
  7. 惠郎、林青丘、林翰佑。疫苗於水殖之重要性:生物科技2005秋季,2005年9月。 PP.24-30。立中大生物科技展中心。
  8. 惠郎。海洋殖50年後可能取代海上捕:海洋高雄期刊第5期,2005年6月。PP.39-42。高雄市政府海洋局。
  9. 惠郎。用疫苗及疾病防系之建立:海洋高雄期刊第6期,2005年9月。PP.39-41。高雄市政府海洋局。
  10. 惠郎。看台海的力:生技季刊2005年第2期。PP.23-24。法人生物技中心。
  11. .2006.生生不息  用微生物生物技之承.九州公司.105-117
  12. 惠郎, 2007. 可在稚促免疫保力之口服疫苗. 成大榕 第一卷第七期 - 2007年10月5日
  13. 惠郎. 2007. 推生技之我. 成大榕 第一卷 第四期 - 2007年9月 14日
  14. 96年度科技年:生物技域
  15. 惠郎.2007.「多快速合核酸探法」技洲基因科技股份有限公司,技金100

研究 (至少五年)

A. 科

  1. 石斑苗之功能性基因研究--石斑菌交互作用之功能性基因研究(2003-2004)
  2. 疫苗--重急性呼吸道症候群病毒具中和抗生能力疫苗抗原及疫苗研究(2004)
  3. 免疫系育之研究(第三年) 科(2003-2004)
  4. 免疫系育之研究(第二年) 科(2002-2003)
  5. 免疫系育之研究(第一年) 科(2001-2002)
  6. 石斑虹彩病毒疫苗 科(2002-20003)
  7. 建立南部生技聚落及法案 科(2001-2002)

C. 一般建教案

  1. 海Streptococcus的 (委,2004)
  2. 口服促技之 (合作富立洋,2004)
  3. 以免疫方法生神死病病毒之石斑苗 (合作富立洋,2004)
  4. 口服促技之 (合作富立洋,2003)
  5. 用生物技研感染胰性疾病次位疫苗 (合作富立洋,2003)
  6. 冬夏草保健食品之研 - 冬夏草菌株DNA分子定方法之建立及其用(台糖公司,2002-2003)
  7. 海菌性疫苗之田(委,2002)
  8. 生物技科技教育改-物基因殖疫苗展技教源中心(教育部,2002)
  9. 海免疫之研 (委,2001)
  10. 推立大研究所基教育重改-成功大生物科技研究暨教育改(教育部,2001)
  11. 水苗系之建立-Ⅰ(水苗,2001)
  12. DNA疫苗技之用(生物技家型,1999-2002)
  13. 水殖疫苗策略(工局,1999-2000)
  14. 用生物技研感染性胰性次元疫苗(生物技家型,1998-2001)

 

指生情 (至少五年)

A. 指生

  1. 永茂(博三)何立平(博二)尤建智(博士)(休中)
  2. 一: 曹儒
  3. 二: 佩芬春美孟妃
  4. 士92: 政隆
  5. 士91: 林青丘、康郁婷
  6. 士90: 、林素卿
  7. 士89:王俊、惠恩

B. 指生之特殊

  1. 指生2002年Hewlett Parker & Far Eastern Economic Review合之“ Young Inventor Award: Bronze Award”(我首次得)

主及 (至少五年)

  1. 主持人,生物科技新知研,台台南, Apr. 1-2, 2002
  2. 主持人,中草科技化研, Dec. 9, 2000
  3. 主持人,中草研, Apr. 2, 1999
  4. 中日水殖科技研,日本,
  5. 第九洲病家,希, Sep. 17, 1999
  6. 台日水生物科技研, 日本, Mar. 11-17, 2000
  7. 第十洲病家, , Sep. 10-14, 2001
  8. 第六洲水年, 台高雄, Nov. 25-30
  9. 生物科技研,台台南, Dec. 13-14

 

料源  http://www.ncku.edu.tw/~biotech/teacher/Huey-Lang%20Yang/c.htm

 

什是成功?

如果在一域面,第一被想到的人,就算是了...

老是成功的人,是不的去思考未的十年要做什,且教我不是科的域,也我在生活度上要有正向思考的能力...的大恩人.


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