V2EX protein folding

Protein Folding

Definition / 释义

protein folding蛋白质折叠。指一条氨基酸链在细胞内或体外通过分子间作用力自发或在伴侣蛋白帮助下,形成具有特定三维结构的过程;该结构通常决定蛋白质的功能。(也常讨论“错误折叠”与疾病相关。)

Pronunciation (IPA) / 发音 (IPA)

/protin fold/

Examples / 例句

Protein folding happens quickly inside cells.
蛋白质折叠在细胞内发生得很快。

Errors in protein folding can lead to aggregates that disrupt normal cellular function.
蛋白质折叠出错可能形成聚集体,从而干扰细胞的正常功能。

Etymology / 词源

protein 源自希腊语 proteios(意为“首要的、最重要的”),强调其在生命中的关键地位;folding 来自动词 fold(折叠、折起)加 -ing 构成名词,表示“折叠这一过程”。合起来直观表达“蛋白质形成折叠结构的过程”。

Related Words / 相关词

Notable Works / 文献与著作中的用例

  • Molecular Biology of the Cell(Alberts 等,《细胞的分子生物学》):讨论蛋白质在细胞内的折叠与分子伴侣作用。
  • Lehninger Principles of Biochemistry(Nelson & Cox,《雷宁格生物化学原理》):介绍蛋白质结构层次与折叠的基本原理。
  • Introduction to Protein Structure(Branden & Tooze,《蛋白质结构导论》):系统讲解折叠、结构稳定性与功能关系。
  • The Protein Folding Problem and Tertiary Structure Prediction(经典综述与研究论文主题):以“蛋白质折叠问题”为核心讨论结构预测与能量景观。
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