V2EX pd-l1

PD-L1

释义 Definition

PD-L1(Programmed Death-Ligand 1,程序性死亡配体1)是一种细胞表面蛋白,常在肿瘤细胞或免疫细胞上表达。它与T细胞上的PD-1受体结合后,会抑制免疫反应,帮助肿瘤“躲过”免疫系统的攻击;因此PD-L1也常作为免疫治疗(免疫检查点抑制剂)相关的生物标志物之一。(该缩写在医学语境中最常见;在其他领域含义较少见。)

发音 Pronunciation (IPA)

/pi di l wn/

例句 Examples

PD-L1 helps some tumors evade the immune system.
PD-L1帮助某些肿瘤逃避免疫系统的攻击。

Patients with high PD-L1 expression may respond better to certain checkpoint inhibitors, although results can vary by cancer type and testing method.
PD-L1高表达的患者可能对某些免疫检查点抑制剂反应更好,但疗效会因癌种与检测方法不同而变化。

词源 Etymology

PD-L1是医学缩写:PD代表“programmed death(程序性死亡)”这一命名传统,L代表“ligand(配体)”,1表示该家族中的一个成员。该术语在免疫学与肿瘤学中用于描述与PD-1通路相关的“免疫刹车”机制,是免疫检查点概念发展后被广泛使用的名称。

相关词 Related Words

文献与著作中的用例 Notable Works

  • Cancer Immunotherapy: PD-1/PD-L1 Pathway Blockade(Pardoll, 2012, Nature Reviews Cancer
  • Safety, Activity, and Immune Correlates of AntiPD-1 Antibody in Cancer(Topalian et al., 2012, New England Journal of Medicine
  • Safety and Activity of AntiPD-L1 Antibody in Patients with Advanced Cancer(Brahmer et al., 2012, New England Journal of Medicine
  • The Hallmarks of Cancer: The Next Generation(Hanahan & Weinberg, 2011, Cell;后续相关综述与版本中常讨论免疫逃逸并引入PD-1/PD-L1通路)
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