V2EX interleukin-23

Interleukin-23

释义 Definition

白细胞介素-23(IL-23):一种由免疫细胞分泌的细胞因子,主要参与炎症反应与免疫调控,尤其与Th17 细胞反应相关;在银屑病、炎症性肠病等疾病的炎症通路中常被提及。(此词也常以缩写 IL-23 出现)

发音 Pronunciation (IPA)

/ntrlukn twnti θri/

例句 Examples

Interleukin-23 helps drive inflammation in some immune responses.
白细胞介素-23 在某些免疫反应中有助于推动炎症发生。

Researchers found that blocking interleukin-23 reduced symptoms in an experimental model of autoimmune disease.
研究人员发现,在一种自身免疫病的实验模型中,阻断白细胞介素-23 能减轻症状。

词源 Etymology

interleukin 来自 inter-(“在……之间”)+ leukin(与 leukocyte “白细胞”同源,源自希腊语 leukos “白色”),原意指“由白细胞相关通路传递、在细胞之间传递信息的物质”;23 表示该类分子在命名体系中的编号。IL-23 由两个亚基组成,其中 p19 是其特征性亚基(并与 IL-12 共享 p40 亚基),因此在免疫学文献中常 IL-12 对照讨论。

相关词 Related Words

文学与著名作品 Notable Works

  • Oppmann, B. et al. “Novel p19 protein engages IL-12p40 to form a cytokine, IL-23” (Immunity, 2000)
  • Cua, D. J. et al. “Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation” (Nature, 2003)
  • The IL-23/IL-17 axis in inflammation” 相关综述(Nature Reviews Immunology 等期刊多篇综述中频繁出现该词)
  • 关于银屑病与炎症性肠病靶向治疗的临床研究与综述(如 New England Journal of MedicineLancet 等医学期刊中常见 IL-23/IL-23p19 抑制剂相关讨论)
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